Recent Publications

Publications originating from the Engelman Lab

(Lab members are highlighted in boldface)

  1. Hatchell KE, Lu Q, Mares JA, Michos ED, Wood AC, Engelman CD. Multi-ethnic analysis shows genetic risk and environmental predictors interact to influence 25(OH)D concentration and optimal vitamin D intake. Genetic Epidemiology. 2019 Dec 12 (Epub ahead of print)
  2. Hatchell KE, Lu Q, Hebbring SJ, Michos ED, Wood AC, Engelman CD. Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations. Hum Genet. 2019 Jul 24 (Epub ahead of print).
  3. Darst BF, Lu Q, Johnson SC, Engelman CD. Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer’s risk factors among 1,111 cohort participants. Genetic Epidemiology. 2019 Sep;43(6):657-674. Figure from publication selected as issue cover.
  4. Darst BF, Koscik RL, Hogan KJ, Johnson SC, Engelman CD, Longitudinal plasma metabolomics of aging and sex. Aging. 2019 Feb 24;11(4):1262-1282. PMCID: PMC6402508.
  5. Darst BF, Engelman CD, Tian Y, Lorenzo Bermejo J. Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20. BMC Genetics. 2018 Sep 17;19(Suppl 1):76. PMCID: PMC6157271.
  6. Darst BF, Malecki KC, Engelman CD. Using recursive feature elimination in random forest to account for correlated variables in high dimensional data. BMC Genetics 2018 Sep 17;19(Suppl 1):65. PMCID: PMC6157185.
  7. Engelman CD, Darst BF, Bilgel M, Vasiljevic E, Koscik RL, Jedynak BM, Johnson SC. The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer’s Prevention. Neurobiology of Aging 2018 Jun;66:177. PMCID: PMC5924624.
  8. Hong J*, Hatchell KE*, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanhgera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT**, Engelman CD**, Billings LK**. Trans-ethnic evaluation identifies novel low frequency loci associated with 25-hydroxyvitamin D concentrations. J Clin Endocrinol Metab 2018 Apr 1;103(4):1380-1392. PMCID: PMC6276579. *Joint first authors; **Joint senior authors (consortium paper)
  9. Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD. Reliability of a novel social activity questionnaire. Journal of Aging and Health 2018 Feb;30(2):305-320.  PMCID: PMC5449232.
  10. Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD. Social support and verbal interaction are differentially associated with cognitive function in midlife and older age. Aging, Neuropsychology and Cognition 2017 Dec 15:1-17 (Epub ahead of print; doi: 10.1080/13825585.2017.1414769). PMCID: PMC6003840
  11. Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD. Pathway-specific polygenic risk scores as predictors of amyloid-b deposition and cognitive function in a sample at increased risk for Alzheimer’s disease. J Alzheimers Dis 2017;55(2):473-484.  PMCID: PMC5123972.
  12. Sippy R, Kolesar JM, Darst BF, Engelman CD. Prioritization of family member sequencing for the detection of rare variants.  BMC Proceedings 2016 Oct 18;10(Suppl 7):227-231.  PMCID: PMC5133500.
  13. Darst BF, Engelman CD. Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals.  BMC Proceedings 2016 Oct 18;10(Suppl 7):203-207.  PMCID: PMC5133523.
  14. Engelman CD, Greenwood CMT, Bailey JN, Cantor RM, Kent JW, Konig IR, Bermejo JL, Melton PE, Santorico SA, Schillert A, Wijsman EM, MacCluer JW, Almasy L. Genetic Analysis Workshop 19: methods and strategies for analyzing human sequence and gene expression data in extended families and unrelated individuals.  BMC Proceedings 2016 Oct 18;10(Suppl 7):67-70.  PMCID: PMC5133501.
  15. Darst BF, Koscik RL, Hermann BP, La Rue A, Sager MA, Johnson SC, Engelman CD. Heritability of Cognitive Traits Among Siblings with a Parental History of Alzheimer’s Disease.  J Alzheimers Dis 2015 Jan; 45(4): 1149-55. PMCID: PMC4398625.
  16. Sung YJ, Korthauer KD, Swartz MD, Engelman CD. Methods for collapsing multiple rare variants in whole genome sequence data.  Genet Epidemiol 2014 Aug; 38(S1): S13-20. PMCID: PMC4558905.
  17. Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ. Prediction of genetic contributions to complex traits using whole genome sequencing data.  BMC Proceedings 2014 Jun; 8(Suppl 1): S68. PMCID: PMC4143683.
  18. Engelman CD, Bo R, Zuelsdorff M, Steltenpohl H, Kirby T, Nieto FJ. Epidemiologic study of the C-3 epimer of 25-hydroxyvitamin D3 in a population-based sample.  Clin Nutr 2014 Jun; 33(3): 421-5. PMCID: PMC3884039.
  19. Engelman CD, Koscik RL, Jonaitis EM, Hermann BP, La Rue A, Sager MA. Investigation of TREM2 variant in the Wisconsin Registry for Alzheimer’s Prevention.  Neurobiology of Aging 2014 Jun; 35(6): 1252-4.  PMCID: PMC3961539.
  20. Engelman CD. Towards personalized prevention of obesity: Can vitamin D negate the FTO effect?  Diabetes 2014 Feb; 63(2): 405-6. (Invited editorial).
  21. Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, La Rue A, Sager MA. Stressful Events, Social Support, and Cognitive Function in Middle-aged Adults with a Family History of Alzheimer’s Disease.  J Aging Health 2013 Sep; 25(6): 944-59.  PMCID: PMC3769466.
  22. Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA. Interaction between two cholesterol metabolism genes influences memory: Findings from the Wisconsin Registry for Alzheimer’s Prevention.  J Alzheimers Dis 2013 Aug; 36(4): 749-57. PMCID: PMC3759032.
  23. Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo, Jr RP, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE. Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations. J Nutr 2013 Jan; 143(1): 17-26.  PMCID: PMC3521459.